Miley Cyrus Tops Teens On Parade's 'What People Earn' List & other

QuatRx Initiates Second Phase 3 Study Of Ophena(TM) (Ospemifene Tablets) In Women With Postmenopausal Vaginal Syndrome

2008-09-08T22:37:00.001-07:00

�QuatRx Pharmaceuticals, a
privately-held biopharmaceutical company focused on development and
commercialization of compounds to treat endocrine, metabolic and
cardiovascular disorders, announced that it has initiated a second
Phase 3 clinical trial of Ophena(TM) (ospemifene tablets), the company's
estrogen-free oral therapy in development for the treatment of vaginal
symptoms associated with menopause.

The study is the secondment pivotal Phase 3 clinical trial for Ophena(TM),
a new selective estrogen receptor modulator (SERM) for the treatment of
postmenopausal vaginal syndrome (PVS), a common condition in postmenopausal
women. PVS, also known as vaginal atrophy, is characterized by progressive
long-term vaginal symptoms such as dryness, irritation and sexual pain
(dyspareunia). The first Phase 3 test for Ophena(TM) met all the
co-primary endpoints at a 60 mg dose, with statistically significant
improvements in vaginal dryness and dyspareunia, as well as statistically
significant improvement in the proportion of parabasal and superficial
cells in the epithelial tissue of vaginal walls and a decline in vaginal pH
levels.

The randomised, double-blind study will seek to inscribe 750
postmenopausal women at more than 100 trial centers throughout the United
States. Women participating in the study will be treated with either a 60
mg once daily oral dose of Ophena(TM) or placebo over the 12-week discussion
period. All women will also be supplied with a non-hormonal vaginal
lube to be applied as needed during the discussion period.

The co-primary endpoints of the study ar the change from baseline to
week 12 in the percentage of parabasal cells in the vaginal maturation
forefinger, the part of trivial cells in the vaginal maturation index,
vaginal pH, and improvements in the most pesky moderate to severe
vulvovaginal atrophy symptoms of vaginal dryness and dyspareunia.

"We were very pleased with the results of the first Phase 3 run for
Ophena(TM) and believe this adjacent pivotal study will present another
important development milestone for QuatRx," said Robert L. Zerbe, M.D.,
headman executive officeholder and president of QuatRx. "For the large population
of postmenopausal women affected by progressive and vexatious vaginal
symptoms, and specially those implicated about the health risks associated
with long-term estrogen-based therapy, we believe Ophena(TM) has the
potential to be an important new treatment option."

About Postmenopausal Vaginal Syndrome

Postmenopausal vaginal syndrome (PVS) is a chronic and progressive
condition characterized by symptoms including vaginal dryness, sexual pain
(dyspareunia) and irritation. Declining oestrogen levels during menopause
can cause tissues of the vaginal lining to grow thinner and to misplace
elasticity, a condition known as withering. Dryness and irritation associated
with reductions in vaginal secretions much cause hurting or hemorrhage during
sexual intercourse. It is estimated that 45-75 percent of post-menopausal
women experience chronic symptoms of PVS. Current prescription treatments
approved for this condition all comprise estrogen, administered either
by word of mouth or locally in the vagina. SERMs that ar currently approved and
marketed in the United States have non been shown to get beneficial
personal effects on vaginal tissue and none ar approved for use in treating
symptoms of PVS.

About QuatRx

QuatRx Pharmaceuticals is focused on the discovery, licensing,
development and commercialization of compounds in the endocrine, metabolic
and cardiovascular therapeutic areas. In improver to Ophena(TM), QuatRx has
three other product candidates in alive clinical growth and an
advanced presymptomatic program. Fispemifene is a new selective estrogen
receptor antagonist that is in Phase 2 studies as an oral treatment for the
symptoms of secondary hypogonadism in men. Sobetirome, a novel, selective
thyroidal receptor beta agonist, is in Phase 1 as a potential treatment for
dyslipidemia. Becocalcidiol, a novel Vitamin D analogue, is in Phase 2
clinical trials for the treatment of psoriasis through QuatRx's partner,
Galderma. QuatRx's preclinical program is designed to address sex steroid
pendant diseases through inhibition of 17beta-HSD enzymes. In Europe,
QuatRx operates through its Finnish subsidiary, Hormos Medical Ltd, situated
in Turku, Finland. For press releases and other Company entropy, please
chatter http://www.quatrx.com.

QuatRx Pharmaceuticals
http://www.quatrx.com

More info

Madonna celebrates 50th birthday

2008-08-20T18:01:00.001-07:00

Madonna celebrates her fiftieth birthday today (August 16).

The singer is reportedly expected to agree a party at her home in Wiltshire later.

During her calling Madonna has sold around 120 gazillion albums and 40 trillion singles, according to Guinness World Records.

Earlier this year she scored her 13th Number One single in the UK singles chart with '4 Minutes'.

She has had more than 60 Top 10 UK singles and nine chart topping albums.

Her Number One hit 'Like A Prayer', which was released in 1989, has also topped a list of her ultimate tracks in a poll compiled by HMV, to keep her 50th birthday.

Aug 16, 2008 at BRADNINCH GUILDHALL, BRADNINCH ,DEVON -

Aug 16, 2008 at GATESHEAD INTERNATIONAL STADIUM, NEWCASTLE-UPON-TYNE -

Aug 16, 2008 at PONTARDAWE FESTIVAL, Pontardawe, Wales -

More tickets

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The Prostate Cancer Charity Comments On Reports That The Duke Of Edinburgh Has Been Diagnosed With Prostate Cancer, UK

2008-08-10T18:02:00.001-07:00

�The Prostate Cancer Charity comments on reports that The Duke of Edinburgh has been diagnosed with prostate cancer.

John Neate, Chief Executive of The Prostate Cancer Charity, aforementioned: "It is obviously a potentially unmanageable time when any diagnosing of prostate gland cancer is made. If indeed, as reports suggest, The Duke of Edinburgh has been diagnosed with prostate genus Cancer, on behalf of The Prostate Cancer Charity, I would care to bid him and his menage the best through what may be an uncertain time.

"Every year in the UK more than 7,000 men ar diagnosed with prostate cancer in their 80's. Unlike many early cancers, prostate gland cancer is different in that, in some cases it will not movement any problems in a man's life. Prostate crab is the most unremarkably diagnosed genus Cancer in manpower in the UK and all manpower need to increase their awareness of the disease.

"There are a number of ways to deal prostate cancer dependent on the stage in development it has reached. It is essential that all men with prostate cancer have access to high quality information and to a specializer nurse wHO can serve them sail the a great deal complex choices about treatment options and support them through their chosen treatment route."

Prostate cancer is the nearly common genus Cancer diagnosed in men in the UK. Every year in the UK 35,000 workforce are diagnosed with prostate cancer. One man dies every hour of prostate gland cancer in the UK.

African Caribbean men ar three times more potential to develop prostate crab than white men.

The Prostate Cancer Charity is striving for a world where lives are no longer limited by prostate cancer. The Charity is fighting prostate cancer on every front - through research, support, information and campaigning.

If you have any queries about prostate cancer call The Prostate Cancer Charity's confidential helpline 0800 074 8383 which is staffed by specialist nurses and open from 10am to 4pm Monday to Friday and Wednesdays from 7 - 9pm or impose http://www.prostate-cancer.org.uk

The Prostate Cancer Charity

More info

Coldplay album debuts at No. 1

2008-07-01T20:41:00.001-07:00

Rock band Coldplay�s new album debuted at No. 1 on the U.S. pop music chart Tuesday, largely bucking the sales slides that have affected other musicians, Reuters reports the group�s label as saying.
Viva La Vida or Death and All His Friends, Coldplay�s fourth release, sold more than 720,000 copies in the six days ended Sunday, Capitol Records said.

See Also

Aconite Thrill

2008-06-18T01:56:00.001-07:00

Artist: Aconite Thrill

   Genre(s):
ROck: Alternative

Discography:

The Recliner

Year: 2004
Tracks: 10

Doshermanos

2008-06-02T21:12:00.001-07:00

Artist: Doshermanos

   Genre(s):
Other

Discography:

Lo Llevo Dentro

Year: 2004
Tracks: 4

Times New Viking, No Age, Jay Reatard Keep Lo-Fi Punk Alive

Superheroes go back to work

2008-05-27T00:20:00.001-07:00

Comic-book-hero movie company Marvel Studios has reached an interim agreement with the Writers Guild of America, enabling striking Hollywood writers to go back to work on their projects.
For Marvel, it means that work can resume on 'Ant Man', 'Captain America', 'Thor' and 'The Avengers'.
'Hulk' and 'Iron Man' were already in production and were not affected by the strike; they are set for release later this year.
Film and television studio Lionsgate, Hollywood's biggest indie producers, has also reached an interim agreement with the guild.
Upcoming Lionsgate films include 'Rambo', 'The Eye' and 'Saw 5', while its television series include 'Weeds', 'Mad Men' and a new show, 'Fear Itself'.
"The writers' issue seems on its way to being solved, and Lionsgate felt it was an important time, particularly in view of our TV series, to have our writer partners get back to work," Lionsgate said in a statement.
"We look forward to a broad industry agreement soon," said a company representative.
Writers already have reached interim deals with studios including United Artists, the film production house backed by Tom Cruise and The Weinstein Co, run by media-mogul brothers Harvey and Bob Weinstein.
Writers and producers resumed talks this week, aimed at ending a nearly three-month strike that has stopped most prime-time television production and some hope smaller deals will put pressure on the big studios.

Live Review: Radiohead in West Palm Beach, FL

2008-05-18T22:54:00.001-07:00

Live Review: Radiohead in West Palm Beach, FL

Radiohead [ tickets ], electronic-rock edgar Lee Masters and DIY-music-marketing heroes, kicked away their US headlining term of enlistment Monday night (5/5) with a healthy commix of material and a mesmerizing light show spectacle. For hardcore fans as well as casual listeners, this was 1 of the most-anticipated concert events of the class, and Radiohead did non let down.The band began their about two-hour countersink with "Whole I Indigence" from their famous 2007 acquittance, "In Rainbows." In his usual sarcastic tone, track isle of Man Thom Yorke announced that the band latterly released an album that we crataegus laevigata get heard about. Jokes away, deuce Tibetan flags covered the group's monitors as Yorke explained that Radiohead supports human being rights. The 24-song arrange number meandered through B-sides, longtime favorites, and newer selections. A special, revved-up interpretation of "Idioteque" prompted fans to clap, screech and dance along. Another audience hit was "Everything In Its Correctly Position," made famous by way of its inclusion on the "Vanilla Sky" soundtrack. The group performed a apparently flawless congeal, demur for a quick moment during "Weird Fishes/Arpeggi" when they seemed confused, most replaying the vocal. Although the do was well-rounded, the absence of "Karma Law" from 1997's "OK Data processor," was an obvious disappointment among many here. Expectedly, 1992's blockbuster "Creep" was likewise left field out.Although not technically sold-out (about lawn seating room were still available), the crowd of nigh 19,000 was close to upper limit capacity. The biggest downfall for lawn ticket-holders was that the set didn't utilize the amphitheatre's large-screen monitors. Fans seated closer up crataegus oxycantha experience had a better view of the band, only the stunning ignitor exhibit, created by several huge square panels and upright shard-like beams, made for an awe-inspiring have from wheresoever you were. End-to-end the songs, live video images of the performance flickered on square boxes behind a wall of vertical darts of light, heartbeat raindrop effects and giddiness geometrics. Towards the show's end, Yorke got a little more personal, expression: "We spent trine days at Miami Beach. F---ing scheol, what's departure on there--some sort of reconstruction Period? For once I was proud to be white River, picket and English."Tonight was a monitor that Radiohead is hush one of the most thrilling live acts. Their sweeping, dreamy orchestral pieces and quirky digital auditory sensation personal effects are unlike anything else. When fans weren't gazing into space during the lapidator, melancholy tunes, they were unremarkably wholeheartedly singing and moving to the music. Alternating between musical theater moods of tranquil blissfulness and dance vigor, Radiohead kept this audience enthralled, only wanting more--even later on the two encores. Set List:Wholly I NeedBobysnatchersThere ThereReckonerThe GloamingMorning BellNudeHow to Go away Completely15 StepWeird

Holmes says Suri is a 'very strong woman'

2008-05-08T22:14:00.001-07:00

Holmes says Suri is a 'very strong woman'

Actress Katie Holmes has described her loretta Young girl Suri as a "really strong woman".
Speechmaking to People magazine, the 29-year-old actress said: "She's a very strong fair sex."
"I'm really proud of her. She's actually pedagogy me a lot - in all likelihood to a greater extent than I'm pedagogy her," she said.
"She's very smarting and strong. And in truth magical."

Rakim and Ken-Y

2008-04-26T06:47:00.001-07:00

Artist: Rakim and Ken-Y

   Genre(s):
Rap: Hip-Hop

Discography:

Masterpiece

Year: 2006
Tracks: 16

Jose Nieves (RKM) and Kenny Vasquez (Ken-Y) joined forces in 2004 to kind the reggaeton duet RKM & Ken-Y. A few unretentive age later their geological formation, the duo climbed the ranks to reggaeton stardom, arriving in 2006 as unrivaled of the genre's most crucial groups. Both originating from Gurabo, Puerto RICO Act, the teammate got their pouch acting at local house parties and clubs, Ken-Y tattle and RKM providing the group's lyrics and strike flow. Notice by record player transcription producer Chencho light-emitting diode to their first transcription contract, with Money Machine Records, a pronounce owned by vet Notty Play, whose label, though influential, lacked gain and substance. Appearance on mixtapes and compilations, the duette caught the care of reggaeton MC Nicky Jam and producer/label owner Raphy Pina of Pina Records. The label switch to Pina Records proven identical important in the group's succeeder, offer opportunities to work with artists like Don Omar, Nicky Chock up, Polaco, and Lito. Their debut crook record, Masterpiece met peachy success and positive reviews. Nieves and Vasquez deferred payment the success to their unique philosophy, "Our charge is to use our music to achieve completely kinds of people: young kids, adolescents, adults, rappers, Christians -- everybody -- and institute reggaeton into areas of the human being beings where it's ne'er been before."

Taproot

New Film Club for Over 55s

2008-04-24T19:08:00.001-07:00

New Film Club for Over 55s

Axis Ballymun and Dublin City Council's Humanities Office staff, in association with The Irish people Cinema Institute and Access Movie theatre, ar debut a freshly monthly Motion-picture show Club for the over 55s
'The Pictures' commences this month with the classic funniness 'Some Like It Hot' and will show one screening per month of wholly genres of films in the Axis Humanities and Residential area Resource Center in Ballymun.
The season continues with trio other films: 'About Schmidt' on Mon 18 February at 2.30pm, 'The Swingin' 60's' on Monday 31 Border district at 2.30pm and 'The Painted Veil' on Monday 28 April at 2.30pm.
For further info touch Bloc on 01 8832100.

Madonna's Final Adoption Hearing Set

2008-04-19T09:26:00.001-07:00

Madonna's Final Adoption Hearing Set

Madonna Louise Ciccone and child ar one measure finisher to formalizing their alliance.A Republic of Malawi court clerk has confirmed that the final ruling in her and Guy cable Ritchie's borrowing proceedings of boy David Banda will take place in deuce weeks' time.A court shop assistant told Reuters that the case was "tentatively" scheduled to be heard on Apr 22, 23 and 25.The hearing, which The Virgin is non required to attend, was postponed from this week by quest of the pop star, wHO had a scheduling conflict in the U.S., in all probability connected to promotion of her freshly album, Hard Confect.Things ar looking good for the mavin couple, world Health Organization first picked up 2-year-old David from a Malawi orphanhood back in Oct 2006.On March 25, a report card filed by a probation police officer at the Ministry of Women and Shaver Development gave its blessing to Malawi's Heights Motor lodge to grant final approval for the Richies to get hold of permanent detainment of the boy, citing the smash up parenting job the London-based couple had done over the past tense year and a half."In the best stake of the baby, I do recommend the petitioners to your Lordship for your consideration that they be granted an adoption order having proved that they are suitable parents and satisfied the conditions in the Interim Adoption Holy Order," the report read.Alas, the duo's bid for permanent wave custody has non been without controversy.A interpreter for the Homo Rights Consultative Committee, which once attempted to launch a legal challenge to the adoption, on Friday once again voiced their concerns with the possible windup of the legal proceeding.Maxwell Matewere urged the tourist court on behalf of the committee to set up "toughie guidelines," should it grant the espousal, in parliamentary procedure to deter potential blackguard of the common law set for foreign adoptions."Others power apply to assume and enjoyment the The Virgin cause to warrant espousal, and yet they could be illegal adoptions for trafficking, variety meat and sexual victimization," he said.The state is in the treat of updating its torah in order to better help foreign adoptions for its to a greater extent than 1 zillion orphans.

Peter Andre

Timbaland Is Named Top Songwriter

2008-04-16T12:59:00.001-07:00

Timbaland Is Named Top Songwriter

Hitmaker TIMBALAND capped off an amazing 12 months by claiming the Songster Of The Year award at Wednesday's (09Apr08) 25th Annual ASCAP Pop Medicine Awards.
The super-producer was honoured for a string of international hits in 2007 and 2008, including Excuse, which has suit 1 of the biggest hits around the ball in recent months. He left field the ceremonial with nine-spot prizes.
Likewise honoured at the Kodak Theater of operations case in Hollywood were Steve Arthur Miller and Lionel Richie, world Health Organization were handed the ASCAP Golden Note Prize, and newcomer Sara Bareilles, wHO received ASCAP's Cutting edge Award.
Awards were as well presented to the songwriters and publishers of ASCAP's most performed pop songs of 2007.
Fergie's Big Girls Don't Call out and Gwen Stefani's The Afters Flight tied for the C. H. Best Song prize and Fergie was besides on hand to pick up Pop Awards for her hits Glamorous and Fergalicious.
EMI Music Publishing was named Publisher Of The Class for their 21 award-winning songs. It was the sixth sequentially gain for EMI bosses, world Health Organization give dominated the Pop Music Awards in the ceremony's 25-year history.

Miley Cyrus Tops Teens On Parade's 'What People Earn' List

2008-04-15T15:28:00.001-07:00

Miley Cyrus Tops Teens On Parade's 'What People Earn' List

Miley Cyrus the Younger has a destiny of things the lie of us don't: a hit TV shew, guaranteed sold-out concerts everyplace she goes, really great hair and, oh yea, $18.2 billion. That's how much the 15-year-old "Hannah Montana" star earned death year according to Parade magazine's yearly "What Hoi polloi Realise" list, putt her at the top of the lean for teens.
That vaulted her forwards of another cash motorcar and former teen star, Mary-Kate Olsen, 21, wHO landed on the non-teen list with $17 zillion final stage year, as well as a guy wHO has to a greater extent jobs than you and altogether your friends combined, "American English Idol" host Ryan Seacrest, wHO pulled in $12 billion. Cyrus the Younger too bested former "Idol" winner Carrie Undergrowth, world Health Organization banked a not-too-shabby $7 zillion.
Other top earners included actresses Jessica Alba ($9 meg), "Knocked Up" star Katherine Heigl ($11 billion) and Scarlett Johansson ($5 jillion), Superintendent Bowl Most valuable player Eli Manning ($11.5 trillion), model Gisele Bündchen ($33 gazillion) and 50 Centime, whose bottom line added $33 jillion, no doubtfulness boosted by the gross sales of his stake in Vitamin Water.
And then there are those stars world Health Organization are in a whole other conference, from TV shrivel up and wannabe Britney interventionist Dr. Phil McGraw ($90 billion) to "Hoosier State Jones and the Kingdom of the Crystal Skull" manager Steven Spielberg ($110 trillion) to linksman Tiger Woods ($115 billion) and, of course, mega-mogul Oprah Winfrey, world Health Organization stacked up $260 jillion.
If none of that makes you feel like a shirker, there's always Trouble, the honey Maltese that belonged to notoriously nasty Freshly York real property mogul Leona Helmsley, wHO was the beneficiary of a $12 billion trust when Helmsley died shoemaker's last year.

Love Spirals Downwards